Syllabus - Bioinformatics (BM604 (A))

Introduction to Bioinformatics

Objectives of bio-informatics, data integration, data analysis, bio-informatics databases and tools. Overview of bio-informatics application.

Molecular Biology and Information

Basic chemistry of nucleic acids, structure of DNA. Genes: - The functional elements in DNA, DNA sequencing and polymeric chain reaction, cloning methodology. Amino acids, protein structure.

Sequence Alignment

Introduction to sequence analysis, models for sequence analysis and their biological motivation. Methods of alignment, usage of gap penalties and scoring matrices. Tools for sequence alignment, multiple sequence alignment. Applications of multiple alignment.

Gene Mapping and Gene expression

Applications of Gene mapping, DNA sequencing, DNA micro arrays, algorithms for gene alignment, genetic code.

Proteomics

Protein structure visualization, protein structure prediction, methods of protein structure for known folds, methods of protein structure for unknown folds. Methods for structure prediction. Phylogenetic trees: rooted and unrooted trees; UPGMA and Fitch- Margoliash method.